ZMIZ2

Across TCGA patient cohorts, ZMIZ2 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZMIZ2-associated genes across cancer lineages are A-Raf_pS299, 4E-BP1, and DJ-1. Each is linked with ZMIZ2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZMIZ2-to-partner and partner-to-ZMIZ2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by ZMIZ2-low versus ZMIZ2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZMIZ2→partner) and Y-score (partner→ZMIZ2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	A-Raf_pS299 →	-0.257	-2.990	.047	.036	3	2
UCEC	4E-BP1 →	+0.380	+2.906	<.001	.001	3	2
SKCM	DJ-1 →	-0.172	-2.098	.028	.018	3	1
UCEC	14-3-3_beta →	-0.105	-2.432	.003	.018	3	1
UCEC	GATA6 →	-0.123	-1.577	.027	.018	3	1
UCEC	ACC1 →	+0.290	+1.887	.026	.029	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

A-Raf_pS299 by ZMIZ2 expression — LUSC

Explore this box plot interactively →