ZMIZ2

Across TCGA cell cohorts, ZMIZ2 mutation is significantly associated with the RNA expression of many other genes, with 144 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZMIZ2-associated genes across cancer lineages are OR4F16, OR4F29, and OR56A5. Each is linked with ZMIZ2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZMIZ2-to-partner and partner-to-ZMIZ2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4F16 grouped by ZMIZ2-low versus ZMIZ2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZMIZ2→partner) and Y-score (partner→ZMIZ2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR4F16 →	+0.037	+3.544	.004	.008	3	2
BLOOD_Leukemia	OR4F29 →	+0.037	+3.544	.004	.008	3	2
BLOOD_Lymphoma	OR56A5 →	+0.060	+3.342	<.001	.008	3	2
LARGE_INTESTINE	ARL6 →	+0.596	+3.364	<.001	.002	3	2
LARGE_INTESTINE	POMGNT2 →	+0.725	+3.364	.006	.002	3	2
LARGE_INTESTINE	S100G →	+0.746	+2.425	.003	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 144 associations by consensus.

OR4F16 by ZMIZ2 expression — BLOOD_Leukemia

Explore this box plot interactively →