ZMIZ1

Across TCGA patient cohorts, ZMIZ1 mutation is significantly associated with the RNA expression of many other genes, with 5,559 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZMIZ1-associated genes across cancer lineages are CRYBB2P1, DNAJC17, and FRA10AC1. Each is linked with ZMIZ1 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZMIZ1-to-partner and partner-to-ZMIZ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CRYBB2P1 grouped by ZMIZ1-low versus ZMIZ1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZMIZ1→partner) and Y-score (partner→ZMIZ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CRYBB2P1 →	+0.361	+1.406	<.001	.002	3	4
COAD	DNAJC17 →	+0.307	+3.240	.005	.008	3	4
COAD	FRA10AC1 →	+0.505	+3.183	.004	.009	3	4
UCEC	EMID1 →	-0.872	-1.726	<.001	.006	3	3
COAD	C19orf54 →	+0.432	+3.352	.003	.005	3	3
UCEC	FOXRED2 →	+0.515	+1.449	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,559 associations by consensus.

CRYBB2P1 by ZMIZ1 expression — UCEC

Explore this box plot interactively →