ZMIZ1

Across TCGA patient cohorts, ZMIZ1 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZMIZ1-associated genes across cancer lineages are ATM, NF2, and PDCD4. Each is linked with ZMIZ1 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZMIZ1-to-partner and partner-to-ZMIZ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ZMIZ1-low versus ZMIZ1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZMIZ1→partner) and Y-score (partner→ZMIZ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.473	-1.736	<.001	<.001	3	4
SKCM	NF2 →	+0.309	+3.169	.013	.018	3	4
UCEC	PDCD4 →	-0.448	-1.347	<.001	.006	3	3
UCEC	Gab2 →	+0.210	+1.347	.040	.006	3	2
UCEC	JNK2 →	+0.222	+2.348	<.001	.002	3	2
UCEC	Ku80 →	+0.188	+1.331	.005	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

ATM by ZMIZ1 expression — UCEC

Explore this box plot interactively →