ZMIZ1

Across TCGA cell cohorts, ZMIZ1 mutation is significantly associated with the RNA expression of many other genes, with 1,558 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZMIZ1-associated genes across cancer lineages are BCAT2, TTC33, and C2orf42. Each is linked with ZMIZ1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZMIZ1-to-partner and partner-to-ZMIZ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BCAT2 grouped by ZMIZ1-low versus ZMIZ1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZMIZ1→partner) and Y-score (partner→ZMIZ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	BCAT2 →	+0.537	+3.351	.006	.003	3	2
LARGE_INTESTINE	TTC33 →	+0.686	+2.458	<.001	<.001	3	2
LARGE_INTESTINE	C2orf42 →	+0.440	+2.339	.002	.009	3	2
BLOOD_Leukemia	OSCP1 →	+0.940	+3.411	<.001	.003	3	2
BLOOD_Leukemia	SLC25A51 →	+0.813	+3.411	<.001	.003	3	2
BLOOD_Leukemia	ULBP2 →	+1.375	+3.351	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,558 associations by consensus.

BCAT2 by ZMIZ1 expression — BLOOD_Leukemia

Explore this box plot interactively →