ZMAT5

Across TCGA patient cohorts, ZMAT5 mutation is significantly associated with the RNA expression of many other genes, with 70 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZMAT5-associated genes across cancer lineages are SNORD114-18, POLR3KP1, and RNU6-1114P. Each is linked with ZMAT5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZMAT5-to-partner and partner-to-ZMAT5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD114-18 grouped by ZMAT5-low versus ZMAT5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZMAT5→partner) and Y-score (partner→ZMAT5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SNORD114-18 →	+0.572	+3.562	<.001	.004	3	2
LUSC	POLR3KP1 →	+0.145	+4.853	<.001	.004	3	2
LUSC	RNU6-1114P →	+0.570	+3.781	<.001	.007	3	2
SKCM	BORCS7-ASMT →	+0.021	+5.037	.001	.009	3	1
UCEC	TSPO2 →	+0.294	+3.545	.003	.007	3	1
UCEC	LILRP1 →	+0.129	+3.645	.004	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 70 associations by consensus.

SNORD114-18 by ZMAT5 expression — UCEC

Explore this box plot interactively →