ZMAT2

Across TCGA patient cohorts, ZMAT2 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZMAT2-associated genes across cancer lineages are Heregulin, INPP4B, and MEK1. Each is linked with ZMAT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZMAT2-to-partner and partner-to-ZMAT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heregulin grouped by ZMAT2-low versus ZMAT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZMAT2→partner) and Y-score (partner→ZMAT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Heregulin →	-0.126	-3.000	.042	.036	3	1
UCEC	INPP4B →	-0.336	-2.308	.038	.036	3	1
UCEC	MEK1 →	+0.502	+2.321	.006	.035	3	1
UCEC	p70-S6K →	+0.262	+2.348	.006	.019	3	1
UCEC	PDCD4 →	-0.530	-2.321	.024	.035	3	1
UCEC	Tuberin →	+0.299	+2.817	.027	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Heregulin by ZMAT2 expression — UCEC

Explore this box plot interactively →