ZMAT1

Across TCGA pan-cancer cohorts, ZMAT1 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ZMAT1 data layer compared with 26 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ZMAT1 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated ZMAT1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

UCEC, LUSC, and SKCM are the cancer types where ZMAT1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	1.000	0.825	.003	36	view →
LUSC	OS	Median	All	0.196	0.663	.001	31	view →
SKCM	DFS	Median	III,IV	0.084	0.663	<.001	12	view →
HNSC	DFS	Median	IV	1.000	0.564	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ZMAT1–UCEC (DFS)

Open the UCEC breakdown →