ZMAT1

Across TCGA patient cohorts, ZMAT1 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZMAT1-associated genes across cancer lineages are S6_pS240_S244, FoxM1, and PCNA. Each is linked with ZMAT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZMAT1-to-partner and partner-to-ZMAT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, S6_pS240_S244 grouped by ZMAT1-low versus ZMAT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZMAT1→partner) and Y-score (partner→ZMAT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	S6_pS240_S244 →	+0.284	+2.115	.024	.017	3	3
UCEC	FoxM1 →	+0.162	+1.415	.044	.010	3	2
UCEC	PCNA →	+0.281	+2.662	<.001	<.001	3	2
UCEC	Rab25 →	-0.283	-1.807	.005	.025	3	2
UCEC	TFRC →	+0.387	+1.415	.018	.010	3	2
UCEC	Bak →	+0.169	+1.415	.030	.040	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

S6_pS240_S244 by ZMAT1 expression — UCEC

Explore this box plot interactively →