ZMAT1

Across TCGA cell cohorts, ZMAT1 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZMAT1-associated genes across cancer lineages are CXorf51B, DEFB4A, and TRIM49B. Each is linked with ZMAT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZMAT1-to-partner and partner-to-ZMAT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CXorf51B grouped by ZMAT1-low versus ZMAT1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZMAT1→partner) and Y-score (partner→ZMAT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CXorf51B →	+1.088	+5.228	.002	.005	3	1
BLOOD_Leukemia	DEFB4A →	+0.191	+5.269	<.001	<.001	3	1
BLOOD_Leukemia	TRIM49B →	+0.140	+4.874	<.001	.002	3	1
BLOOD_Leukemia	CFHR2 →	+0.296	+4.539	<.001	.007	3	1
LARGE_INTESTINE	CLDN17 →	+0.052	+3.930	.001	.003	3	1
LARGE_INTESTINE	SSMEM1 →	+0.023	+3.707	.008	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

CXorf51B by ZMAT1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →