Across TCGA pan-cancer cohorts, ZKSCAN8 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ZKSCAN8 data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ZKSCAN8 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ZKSCAN8 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, CCRCC, and PDAC are the cancer types where ZKSCAN8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	IV	0.841	0.530	.033	8	view →
CCRCC	OS	Median	III,IV	0.964	0.641	.016	6	view →
PDAC	DFS	Median	All	0.588	0.896	.025	5	view →
GBM	OS	Median	All	0.746	0.878	.034	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: ZKSCAN8 tumor-vs-normal RNA expression · all ZKSCAN8 data types