Across TCGA patient cohorts, ZKSCAN8 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZKSCAN8-associated genes across cancer lineages are 14-3-3_beta, eEF2, and eIF4E. Each is linked with ZKSCAN8 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZKSCAN8-to-partner and partner-to-ZKSCAN8 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZKSCAN8→partner) and Y-score (partner→ZKSCAN8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.084	-1.673	.018	.040	3	1
UCEC	eEF2 →	+0.267	+3.169	.034	.018	3	1
UCEC	eIF4E →	+0.213	+2.415	.004	.003	3	1
UCEC	ERK2 →	+0.138	+1.906	.043	.015	3	1
UCEC	JNK2 →	+0.190	+2.196	.006	.032	3	1
UCEC	MEK1 →	+0.447	+2.662	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Exploration

ZKSCAN8 survival (RNA) · tumor vs normal (RNA) · all ZKSCAN8 data types