Across TCGA cell cohorts, ZKSCAN8 mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ZKSCAN8-associated genes across cancer lineages are GPIHBP1, OR12D3, and TOPAZ1. Each is linked with ZKSCAN8 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZKSCAN8-to-partner and partner-to-ZKSCAN8 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZKSCAN8→partner) and Y-score (partner→ZKSCAN8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	GPIHBP1 →	+0.032	+3.129	.002	.007	3	1
LUNG_NSCLC_LUAD	OR12D3 →	+0.056	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	TOPAZ1 →	+0.013	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	ARGFX →	+0.032	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR2B3 →	+0.022	+5.228	<.001	.005	3	1
BLOOD_Leukemia	GFRA4 →	+0.308	+4.409	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Exploration

ZKSCAN8 survival (RNA) · tumor vs normal (RNA) · all ZKSCAN8 data types