Across TCGA pan-cancer cohorts, ZKSCAN7P1 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of ZKSCAN7P1’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where ZKSCAN7P1 RNA is repressed in tumor relative to normal tissue. In most cancer types ZKSCAN7P1 is over-expressed in tumor, although a few such as BRCA and KIRC show the opposite, repressed pattern.
BRCA and KIRC are the cancer types where ZKSCAN7P1 tumor–normal differential expression is most reproducible.