Across TCGA pan-cancer cohorts, ZKSCAN4 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ZKSCAN4 data layer compared with 24 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ZKSCAN4 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated ZKSCAN4 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, CHOL, and SCLC are the cancer types where ZKSCAN4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	1.000	0.616	.003	36	view →
CHOL	OS	Median	All	0.019	0.800	<.001	24	view →
SCLC	OS	Median	III,IV	0.055	0.631	<.001	12	view →
SKCM	DFS	Median	IV	0.036	0.433	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: ZKSCAN4 tumor-vs-normal RNA expression · all ZKSCAN4 data types