Across TCGA patient cohorts, ZKSCAN4 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZKSCAN4-associated genes across cancer lineages are C-Raf, eIF4E, and A-Raf_pS299. Each is linked with ZKSCAN4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZKSCAN4-to-partner and partner-to-ZKSCAN4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZKSCAN4→partner) and Y-score (partner→ZKSCAN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.203	+2.321	<.001	.001	3	2
UCEC	eIF4E →	+0.167	+2.335	.028	.018	3	1
UCEC	A-Raf_pS299 →	-0.136	-2.700	.001	.006	3	1
UCEC	INPP4B →	-0.301	-3.807	.009	<.001	3	1
UCEC	IRS1 →	+0.158	+1.584	.034	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.208	-2.415	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Exploration

ZKSCAN4 survival (RNA) · tumor vs normal (RNA) · all ZKSCAN4 data types