Across TCGA pan-cancer cohorts, ZKSCAN3 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated ZKSCAN3 data layer compared with 27 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ZKSCAN3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ZKSCAN3 expression acts as an unfavorable survival marker.

KIRC and ACC are the cancer types where ZKSCAN3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.141	0.655	.026	12	view →
ACC	OS	Median	All	0.118	0.624	.038	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: ZKSCAN3 tumor-vs-normal RNA expression · all ZKSCAN3 data types