Across TCGA pan-cancer cohorts, ZKSCAN3 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated ZKSCAN3 data layer compared with 27 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher ZKSCAN3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZKSCAN3 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

GBM and LSCC are the cancer types where ZKSCAN3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Median	All	0.358	0.855	.013	9	view →
LSCC	OS	Quartile	II,III,IV	0.917	0.564	.039	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: ZKSCAN3 tumor-vs-normal RNA expression · all ZKSCAN3 data types