ZKSCAN2

Across TCGA patient cohorts, ZKSCAN2 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZKSCAN2-associated genes across cancer lineages are FoxM1, Notch1, and p27_pT198. Each is linked with ZKSCAN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZKSCAN2-to-partner and partner-to-ZKSCAN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by ZKSCAN2-low versus ZKSCAN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZKSCAN2→partner) and Y-score (partner→ZKSCAN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.214	+1.999	.006	<.001	3	2
UCEC	Notch1 →	+0.170	+2.183	<.001	.001	3	2
UCEC	p27_pT198 →	+0.069	+1.415	.033	.043	3	2
UCEC	PCNA →	+0.285	+1.999	<.001	<.001	3	2
UCEC	ATM →	-0.599	-2.571	<.001	<.001	3	2
UCEC	4E-BP1_pT37_T46 →	-0.237	-1.571	.036	.032	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

FoxM1 by ZKSCAN2 expression — UCEC

Explore this box plot interactively →