ZKSCAN2

Across TCGA cell cohorts, ZKSCAN2 mutation is significantly associated with the RNA expression of many other genes, with 76 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZKSCAN2-associated genes across cancer lineages are MMP27, OR5C1, and CST5. Each is linked with ZKSCAN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZKSCAN2-to-partner and partner-to-ZKSCAN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MMP27 grouped by ZKSCAN2-low versus ZKSCAN2-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZKSCAN2→partner) and Y-score (partner→ZKSCAN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	MMP27 →	+0.038	+4.459	<.001	<.001	3	2
CNS	OR5C1 →	+0.042	+3.449	<.001	.004	3	2
BLOOD_Leukemia	CST5 →	+0.403	+3.551	<.001	.009	3	2
BLOOD_Lymphoma	GHSR →	+0.144	+3.180	<.001	.004	3	2
BLOOD_Lymphoma	USP17L7 →	+0.019	+2.874	.001	.009	3	2
SKIN	TSHB →	+0.109	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 76 associations by consensus.

MMP27 by ZKSCAN2 expression — CNS

Explore this box plot interactively →