ZKSCAN1

Across TCGA patient cohorts, ZKSCAN1 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZKSCAN1-associated genes across cancer lineages are eIF4E, eIF4G, and FoxM1. Each is linked with ZKSCAN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZKSCAN1-to-partner and partner-to-ZKSCAN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ZKSCAN1-low versus ZKSCAN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZKSCAN1→partner) and Y-score (partner→ZKSCAN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.181	+3.183	.028	.009	3	1
UCEC	eIF4G →	+0.308	+3.169	.011	.018	3	1
UCEC	FoxM1 →	+0.201	+2.179	.048	.034	3	1
UCEC	GAPDH →	+0.556	+3.700	.008	.001	3	1
UCEC	HER3_pY1289 →	+0.067	+3.189	.048	.010	3	1
UCEC	Heregulin →	-0.139	-2.000	.004	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

eIF4E by ZKSCAN1 expression — UCEC

Explore this box plot interactively →