ZKSCAN1

Across TCGA cell cohorts, ZKSCAN1 mutation is significantly associated with the RNA expression of many other genes, with 167 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZKSCAN1-associated genes across cancer lineages are IZUMO2, KRTAP10-1, and OR4D6. Each is linked with ZKSCAN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZKSCAN1-to-partner and partner-to-ZKSCAN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IZUMO2 grouped by ZKSCAN1-low versus ZKSCAN1-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZKSCAN1→partner) and Y-score (partner→ZKSCAN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	IZUMO2 →	+0.043	+4.906	<.001	.006	3	2
LARGE_INTESTINE	KRTAP10-1 →	+0.003	+2.678	.001	.005	3	2
OESOPHAGUS	OR4D6 →	+0.013	+4.906	<.001	.006	3	1
OESOPHAGUS	DGAT2L6 →	+0.006	+4.906	<.001	.006	3	1
OESOPHAGUS	KRTAP17-1 →	+0.023	+4.906	<.001	.006	3	1
SOFT_TISSUE	H2BC1 →	+0.325	+4.977	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 167 associations by consensus.

IZUMO2 by ZKSCAN1 expression — OESOPHAGUS

Explore this box plot interactively →