ZIM3

Across TCGA pan-cancer cohorts, ZIM3 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ZIM3 data layer compared with 20 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ZIM3 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated ZIM3 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUSC show a favorable association.

UCEC, SCLC, and LIHC are the cancer types where ZIM3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	1.000	0.434	.008	34	view →
SCLC	OS	Median	II,III,IV	0.164	0.712	<.001	30	view →
LIHC	OS	Median	All	0.423	0.785	.005	5	view →
LUSC	DFS	Median	All	0.783	0.376	.015	4	view →
SKCM	DFS	Median	III,IV	0.331	0.673	.012	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ZIM3–UCEC (DFS)

Open the UCEC breakdown →