ZIK1

Across TCGA pan-cancer cohorts, ZIK1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ZIK1 data layer compared with 24 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher ZIK1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ZIK1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LIHC, BLCA, and UCEC are the cancer types where ZIK1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.093	0.783	<.001	30	view →
BLCA	OS	Median	All	0.188	0.687	.020	6	view →
UCEC	DFS	Median	All	0.961	0.618	.015	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

ZIK1–LIHC (OS)

Open the LIHC breakdown →