ZIC3

Across TCGA patient cohorts, ZIC3 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,827 significant associations in total. STAD shows the largest number of these associations.

The most reproducible ZIC3-associated GO terms across cancer lineages are Positive regulation of DNA metabolic process, Negative regulation of chromosome organization, and Positive regulation of chromosome organization. Each is linked with ZIC3 in more than 12 cancer types. Because this analysis shows association rather than direction, both ZIC3-to-partner and partner-to-ZIC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of DNA metabolic process grouped by ZIC3-low versus ZIC3-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZIC3→partner) and Y-score (partner→ZIC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Positive regulation of DNA metabolic process →	+0.059	+0.053	<.001	<.001	3	13
STAD	Negative regulation of chromosome organization →	+0.060	+0.049	<.001	<.001	3	12
STAD	Positive regulation of chromosome organization →	+0.074	+0.063	<.001	.001	3	12
STAD	Regulation of DNA repair →	+0.059	+0.051	<.001	<.001	3	12
STAD	Mitotic spindle assembly →	+0.100	+0.075	<.001	<.001	3	12
STAD	Microtubule cytoskeleton organization involved in mitosis →	+0.105	+0.067	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,827 associations by consensus.

Positive regulation of DNA metabolic process by ZIC3 expression — STAD

Explore this box plot interactively →