ZIC3

Across TCGA patient cohorts, ZIC3 mutation is significantly associated with the RNA expression of many other genes, with 3,768 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZIC3-associated genes across cancer lineages are FABP6, RNU6-1213P, and RNA5SP411. Each is linked with ZIC3 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZIC3-to-partner and partner-to-ZIC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FABP6 grouped by ZIC3-low versus ZIC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZIC3→partner) and Y-score (partner→ZIC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FABP6 →	-1.227	-1.711	<.001	<.001	3	3
UCEC	RNU6-1213P →	+0.132	+2.951	<.001	<.001	3	3
UCEC	RNA5SP411 →	+0.731	+1.343	<.001	.004	3	2
CESC	RNA5SP336 →	+0.099	+4.030	.004	.008	3	2
LUAD	TRAJ49 →	+0.648	+2.372	.001	.007	3	2
UCEC	LINC00458 →	+0.121	+1.554	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,768 associations by consensus.

FABP6 by ZIC3 expression — UCEC

Explore this box plot interactively →