ZIC3

Across TCGA patient cohorts, ZIC3 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZIC3-associated genes across cancer lineages are eIF4E, p27_pT198, and Rab11. Each is linked with ZIC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZIC3-to-partner and partner-to-ZIC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ZIC3-low versus ZIC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZIC3→partner) and Y-score (partner→ZIC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.152	+2.263	.012	<.001	3	2
UCEC	p27_pT198 →	+0.075	+1.347	.014	.006	3	2
UCEC	Rab11 →	-0.098	-1.415	.018	.040	3	2
UCEC	Src_pY416 →	-0.146	-1.156	.035	.017	3	2
UCEC	Cyclin-B1 →	+0.679	+1.736	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.072	-2.388	.012	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

eIF4E by ZIC3 expression — UCEC

Explore this box plot interactively →