ZIC3

Across TCGA cell cohorts, ZIC3 RNA expression is significantly associated with the go_rna of many other GO terms, with 700 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ZIC3-associated GO terms across cancer lineages are Zymogen activation, Germ-line stem cell population maintenance, and Presynaptic active zone assembly. Each is linked with ZIC3 in more than 4 cancer types. Because this analysis shows association rather than direction, both ZIC3-to-partner and partner-to-ZIC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Zymogen activation grouped by ZIC3-low versus ZIC3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZIC3→partner) and Y-score (partner→ZIC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Zymogen activation →	-0.167	-0.873	.007	.006	3	5
LUNG_SCLC	Germ-line stem cell population maintenance →	+0.863	+2.372	<.001	<.001	3	4
BONE	Presynaptic active zone assembly →	+1.305	+1.058	<.001	<.001	3	4
BONE	Electron transport chain →	+0.058	+0.996	.001	.001	3	4
LUNG_NSCLC_LUAD	Positive regulation of sodium ion transport →	-0.143	-0.121	<.001	.009	3	3
LUNG_NSCLC_LUAD	Potassium ion import across plasma membrane →	-0.120	-0.183	.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 700 associations by consensus.

Zymogen activation by ZIC3 expression — BONE

Explore this box plot interactively →