ZIC3

Across TCGA cell cohorts, ZIC3 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZIC3-associated genes across cancer lineages are OR10A5, CST9L, and RLN3. Each is linked with ZIC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZIC3-to-partner and partner-to-ZIC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10A5 grouped by ZIC3-low versus ZIC3-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZIC3→partner) and Y-score (partner→ZIC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OR10A5 →	+0.036	+4.029	<.001	.009	3	2
SOFT_TISSUE	CST9L →	+0.028	+5.369	<.001	.004	3	1
SOFT_TISSUE	RLN3 →	+0.059	+5.369	<.001	.004	3	1
SOFT_TISSUE	OR4X2 →	+0.032	+5.369	<.001	.004	3	1
BLOOD_Myeloma	KRTAP19-3 →	+0.236	+4.807	<.001	.006	3	1
LARGE_INTESTINE	RSPH6A →	+0.155	+3.866	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

OR10A5 by ZIC3 expression — OVARY

Explore this box plot interactively →