ZIC2

Across TCGA patient cohorts, ZIC2 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZIC2-associated genes across cancer lineages are EGFR_pY1068, FOXO3a, and JNK2. Each is linked with ZIC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZIC2-to-partner and partner-to-ZIC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ZIC2-low versus ZIC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZIC2→partner) and Y-score (partner→ZIC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.245	-2.115	.025	.019	3	1
UCEC	FOXO3a →	-0.135	-2.102	.002	.019	3	1
UCEC	JNK2 →	+0.225	+2.115	.009	.019	3	1
UCEC	p21 →	+0.178	+2.820	.034	.035	3	1
UCEC	Annexin-1 →	+0.603	+2.341	.008	.019	3	1
UCEC	S6_pS240_S244 →	+0.391	+2.115	.027	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

EGFR_pY1068 by ZIC2 expression — UCEC

Explore this box plot interactively →