ZIC2

Across TCGA cell cohorts, ZIC2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,636 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ZIC2-associated GO terms across cancer lineages are Ribosomal protein import into nucleus, 'de novo' IMP biosynthetic process, and Locomotory exploration behavior. Each is linked with ZIC2 in more than 7 cancer types. Because this analysis shows association rather than direction, both ZIC2-to-partner and partner-to-ZIC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ribosomal protein import into nucleus grouped by ZIC2-low versus ZIC2-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZIC2→partner) and Y-score (partner→ZIC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Ribosomal protein import into nucleus →	+0.089	+1.228	<.001	<.001	3	8
BREAST	'de novo' IMP biosynthetic process →	+0.114	+1.178	<.001	<.001	3	7
STOMACH	Locomotory exploration behavior →	+0.202	+1.131	.005	.007	2	7
BONE	RNA surveillance →	+0.079	+3.171	<.001	<.001	3	6
BONE	Nuclear RNA surveillance →	+0.093	+3.738	<.001	<.001	3	6
LUNG_NSCLC_LUSC	Regulation of thymocyte migration →	-1.611	-1.530	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,636 associations by consensus.

Ribosomal protein import into nucleus by ZIC2 expression — BREAST

Explore this box plot interactively →