ZIC2

Across TCGA cell cohorts, ZIC2 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ZIC2-associated genes across cancer lineages are SPACA7, C1orf87, and OR1M1. Each is linked with ZIC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZIC2-to-partner and partner-to-ZIC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPACA7 grouped by ZIC2-low versus ZIC2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZIC2→partner) and Y-score (partner→ZIC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SPACA7 →	+0.239	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	C1orf87 →	+0.056	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	OR1M1 →	+0.019	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	OR9A2 →	+0.018	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	IQCF5 →	+0.134	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	SCYGR1 →	+0.596	+4.867	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

SPACA7 by ZIC2 expression — BLOOD_Lymphoma

Explore this box plot interactively →