ZIC1

Across TCGA patient cohorts, ZIC1 mutation is significantly associated with the RNA expression of many other genes, with 6,441 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZIC1-associated genes across cancer lineages are GTPBP3, UBE2T, and KIF20A. Each is linked with ZIC1 in more than 5 cancer types. Because this analysis shows association rather than direction, both ZIC1-to-partner and partner-to-ZIC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GTPBP3 grouped by ZIC1-low versus ZIC1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZIC1→partner) and Y-score (partner→ZIC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	GTPBP3 →	+0.541	+3.220	.002	.009	3	6
UCEC	UBE2T →	+0.569	+1.471	<.001	<.001	3	6
STAD	KIF20A →	+0.763	+3.182	.007	.009	3	5
UCEC	PCLAF →	+0.720	+1.750	<.001	<.001	3	5
UCEC	CDK1 →	+0.680	+1.606	<.001	<.001	3	5
SKCM	TROAP →	+0.747	+3.331	.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,441 associations by consensus.

GTPBP3 by ZIC1 expression — BLCA

Explore this box plot interactively →