ZIC1

Across TCGA patient cohorts, ZIC1 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZIC1-associated genes across cancer lineages are PCNA, TFRC, and 4E-BP1. Each is linked with ZIC1 in more than 4 cancer types. Because this analysis shows association rather than direction, both ZIC1-to-partner and partner-to-ZIC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by ZIC1-low versus ZIC1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZIC1→partner) and Y-score (partner→ZIC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	PCNA →	+0.189	+1.687	.010	.013	3	5
LUSC	TFRC →	+0.637	+2.700	.007	.005	3	4
UCEC	4E-BP1 →	+0.211	+1.999	.005	.008	3	4
UCEC	Cyclin-B1 →	+0.506	+1.736	.001	.006	3	4
COAD	RAD51 →	+0.170	+2.330	.017	.020	3	4
UCEC	eIF4E →	+0.158	+2.820	.007	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

PCNA by ZIC1 expression — LUSC

Explore this box plot interactively →