ZIC1

Across TCGA cell cohorts, ZIC1 mutation is significantly associated with the RNA expression of many other genes, with 1,059 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZIC1-associated genes across cancer lineages are CBX7, BCKDK, and CAMTA2. Each is linked with ZIC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZIC1-to-partner and partner-to-ZIC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CBX7 grouped by ZIC1-low versus ZIC1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZIC1→partner) and Y-score (partner→ZIC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CBX7 →	+0.626	+2.043	.008	.001	3	2
LARGE_INTESTINE	BCKDK →	+0.437	+3.169	.007	.006	3	2
LARGE_INTESTINE	CAMTA2 →	+0.810	+2.584	<.001	.002	3	2
LARGE_INTESTINE	DPH1 →	+0.608	+2.222	.001	.001	3	2
LARGE_INTESTINE	HIPK3 →	+0.497	+2.545	.001	<.001	3	2
LARGE_INTESTINE	LANCL1 →	+0.877	+2.545	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,059 associations by consensus.

CBX7 by ZIC1 expression — LARGE_INTESTINE

Explore this box plot interactively →