ZHX3

Across TCGA pan-cancer cohorts, ZHX3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ZHX3 data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher ZHX3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ZHX3 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

LUAD, UCEC, and HNSC are the cancer types where ZHX3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	All	1.000	0.546	.001	18	view →
UCEC	OS	Median	III,IV	0.433	1.000	.007	14	view →
HNSC	DFS	Tertile	All	0.527	0.744	.021	13	view →
PDAC	OS	Median	All	0.590	0.353	.011	7	view →
CCRCC	DFS	Median	All	0.837	0.652	.032	2	view →
LSCC	OS	Tertile	II,III,IV	0.842	1.000	.041	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ZHX3–LUAD (OS)

Open the LUAD breakdown →