ZHX3

Across TCGA cell cohorts, ZHX3 mutation is significantly associated with the RNA expression of many other genes, with 507 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZHX3-associated genes across cancer lineages are MAGEB4, MYH2, and POLDIP3. Each is linked with ZHX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZHX3-to-partner and partner-to-ZHX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by ZHX3-low versus ZHX3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZHX3→partner) and Y-score (partner→ZHX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.009	+3.192	<.001	.002	3	2
STOMACH	MYH2 →	+0.030	+4.129	.007	.007	3	1
LARGE_INTESTINE	POLDIP3 →	+0.595	+3.192	.004	.007	3	1
LARGE_INTESTINE	TNRC6B →	+0.953	+3.212	<.001	.006	3	1
LARGE_INTESTINE	EP300 →	+0.826	+3.212	.006	.006	3	1
LARGE_INTESTINE	SCML2 →	+1.002	+3.237	.006	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 507 associations by consensus.

MAGEB4 by ZHX3 expression — LARGE_INTESTINE

Explore this box plot interactively →