ZHX2

Across TCGA patient cohorts, ZHX2 mutation is significantly associated with the RNA expression of many other genes, with 3,313 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZHX2-associated genes across cancer lineages are ENO2, UQCR10, and ALDOA. Each is linked with ZHX2 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZHX2-to-partner and partner-to-ZHX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ENO2 grouped by ZHX2-low versus ZHX2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZHX2→partner) and Y-score (partner→ZHX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ENO2 →	+0.864	+2.089	.005	.001	3	4
STAD	UQCR10 →	+0.508	+3.476	.002	.002	3	4
STAD	ALDOA →	+0.746	+3.359	<.001	.004	3	4
SKCM	COPS9 →	+0.287	+2.260	.007	.005	3	4
UCEC	NANS →	+0.373	+2.212	.001	.001	3	4
UCEC	TIMM13 →	+0.353	+2.483	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,313 associations by consensus.

ENO2 by ZHX2 expression — SKCM

Explore this box plot interactively →