ZHX2

Across TCGA cell cohorts, ZHX2 mutation is significantly associated with the RNA expression of many other genes, with 1,376 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZHX2-associated genes across cancer lineages are METTL4, GFM2, and ZNF286A. Each is linked with ZHX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZHX2-to-partner and partner-to-ZHX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, METTL4 grouped by ZHX2-low versus ZHX2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZHX2→partner) and Y-score (partner→ZHX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	METTL4 →	+0.647	+2.502	<.001	.005	3	2
BLOOD_Leukemia	GFM2 →	+0.363	+3.199	.009	.007	3	2
BLOOD_Leukemia	ZNF286A →	+1.283	+3.259	.002	.006	3	2
BLOOD_Leukemia	LRIT2 →	+0.082	+2.684	<.001	.004	3	2
BLOOD_Leukemia	SFT2D2 →	+0.549	+3.199	.003	.007	3	2
LARGE_INTESTINE	UFSP2 →	+0.638	+3.404	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,376 associations by consensus.

METTL4 by ZHX2 expression — LARGE_INTESTINE

Explore this box plot interactively →