ZHX2

Across TCGA cell cohorts, ZHX2 mutation is significantly associated with the mutation status of many other genes, with 7,025 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZHX2-associated genes across cancer lineages are CHD8, OSBPL3, and ARHGAP45. Each is linked with ZHX2 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZHX2-to-partner and partner-to-ZHX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHD8 grouped by ZHX2-low versus ZHX2-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZHX2→partner) and Y-score (partner→ZHX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CHD8 →	+5.115	+5.115	.005	.005	1	4
BREAST	OSBPL3 →	+4.442	+5.095	.001	.001	1	4
LARGE_INTESTINE	ARHGAP45 →	+4.056	+4.510	<.001	<.001	1	4
LARGE_INTESTINE	IFT140 →	+2.044	+3.017	<.001	<.001	1	4
LARGE_INTESTINE	VEPH1 →	+3.182	+2.584	<.001	<.001	1	4
LARGE_INTESTINE	CEP290 →	+2.012	+2.371	.001	.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,025 associations by consensus.

CHD8 by ZHX2 expression — PANCREAS

Explore this box plot interactively →