ZGRF1

Across TCGA patient cohorts, ZGRF1 mutation is significantly associated with the RNA expression of many other genes, with 5,063 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZGRF1-associated genes across cancer lineages are EME1, UBE2T, and COX18. Each is linked with ZGRF1 in more than 4 cancer types. Because this analysis shows association rather than direction, both ZGRF1-to-partner and partner-to-ZGRF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EME1 grouped by ZGRF1-low versus ZGRF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZGRF1→partner) and Y-score (partner→ZGRF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EME1 →	+0.629	+2.198	<.001	<.001	3	5
UCEC	UBE2T →	+0.447	+1.265	.002	.002	3	5
UCEC	COX18 →	+0.426	+1.509	<.001	<.001	3	4
UCEC	H2AZ1 →	+0.544	+2.032	<.001	<.001	3	4
UCEC	MAD2L1 →	+0.588	+1.384	<.001	<.001	3	4
UCEC	NOP10 →	+0.410	+1.662	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,063 associations by consensus.

EME1 by ZGRF1 expression — UCEC

Explore this box plot interactively →