ZGRF1

Across TCGA patient cohorts, ZGRF1 mutation is significantly associated with the total protein of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZGRF1-associated genes across cancer lineages are Shc_pY317, INPP4B, and PDCD4. Each is linked with ZGRF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZGRF1-to-partner and partner-to-ZGRF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by ZGRF1-low versus ZGRF1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZGRF1→partner) and Y-score (partner→ZGRF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	Shc_pY317 →	+0.244	+2.833	.024	.031	3	2
COAD	INPP4B →	-0.509	-3.321	.002	.009	3	2
COAD	PDCD4 →	-0.536	-3.450	.004	.005	3	2
COAD	ATM →	-0.688	-3.169	<.001	.018	2	3
COAD	Caspase-7-cleavedD198 →	+1.113	+3.016	.001	.018	3	2
COAD	Cyclin-E2 →	+0.270	+2.195	.010	.032	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

Shc_pY317 by ZGRF1 expression — CESC

Explore this box plot interactively →