Across TCGA pan-cancer cohorts, ZGLP1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ZGLP1 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in brain lower grade glioma (LGG), where higher ZGLP1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZGLP1 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

LGG, UCEC, and SKCM are the cancer types where ZGLP1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.110	0.833	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
SKCM	DFS	Median	II,III,IV	1.000	0.249	.025	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: ZGLP1 tumor-vs-normal RNA expression · all ZGLP1 data types