ZFYVE9

Across TCGA patient cohorts, ZFYVE9 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZFYVE9-associated genes across cancer lineages are 4E-BP1, JNK2, and Caspase-7-cleavedD198. Each is linked with ZFYVE9 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZFYVE9-to-partner and partner-to-ZFYVE9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by ZFYVE9-low versus ZFYVE9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFYVE9→partner) and Y-score (partner→ZFYVE9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.195	+1.277	.010	.026	3	4
UCEC	JNK2 →	+0.193	+1.447	<.001	.002	3	3
UCEC	Caspase-7-cleavedD198 →	+0.339	+0.947	.042	.047	3	3
UCEC	C-Raf →	+0.136	+1.632	<.001	<.001	3	3
BLCA	MSH2 →	+0.215	+2.115	.022	.018	3	2
COAD	BRD4 →	+0.299	+2.321	.042	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

4E-BP1 by ZFYVE9 expression — UCEC

Explore this box plot interactively →