ZFYVE26

Across TCGA pan-cancer cohorts, ZFYVE26 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated ZFYVE26 data layer compared with 23 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher ZFYVE26 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ZFYVE26 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUSC show a favorable association.

COAD, MESO, and PAAD are the cancer types where ZFYVE26 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.192	0.702	<.001	22	view →
MESO	DFS	Median	III,IV	0.082	0.414	.007	18	view →
PAAD	DFS	Median	II,III,IV	0.175	0.441	.012	12	view →
OV	OS	Median	IV	0.033	0.773	<.001	12	view →
ESCA	OS	Median	II,III,IV	0.206	0.686	.004	12	view →
LIHC	OS	Median	III,IV	0.174	0.654	.001	8	view →
ACC	OS	Median	All	0.118	0.624	.038	6	view →
UCEC	OS	Median	All	0.942	0.861	.034	6	view →
PRAD	DFS	Median	All	0.617	0.886	.045	6	view →
BLCA	OS	Median	All	0.396	0.695	.022	6	view →
LUSC	DFS	Median	III,IV	1.000	0.334	.024	4	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

ZFYVE26–COAD (OS)

Open the COAD breakdown →