ZFYVE26

Across TCGA patient cohorts, ZFYVE26 mutation is significantly associated with the total protein of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZFYVE26-associated genes across cancer lineages are Notch1, Caspase-7-cleavedD198, and Cyclin-B1. Each is linked with ZFYVE26 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZFYVE26-to-partner and partner-to-ZFYVE26 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by ZFYVE26-low versus ZFYVE26-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFYVE26→partner) and Y-score (partner→ZFYVE26) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.119	+1.335	.001	.005	3	4
COAD	Caspase-7-cleavedD198 →	+0.999	+3.476	<.001	.002	3	4
SKCM	Cyclin-B1 →	+0.417	+2.334	.012	.018	3	4
SKCM	14-3-3_zeta →	+0.185	+3.169	.030	.018	3	4
LUSC	NDRG1_pT346 →	+0.888	+2.594	.017	.006	3	3
STAD	c-Kit →	-0.402	-3.000	.014	.036	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

Notch1 by ZFYVE26 expression — UCEC

Explore this box plot interactively →