ZFYVE21

Across TCGA patient cohorts, ZFYVE21 mutation is significantly associated with the RNA expression of many other genes, with 83 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZFYVE21-associated genes across cancer lineages are LINC01784, CPE, and NECTIN2. Each is linked with ZFYVE21 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZFYVE21-to-partner and partner-to-ZFYVE21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01784 grouped by ZFYVE21-low versus ZFYVE21-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFYVE21→partner) and Y-score (partner→ZFYVE21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	LINC01784 →	+0.179	+7.924	<.001	.008	3	2
UCEC	CPE →	-1.079	-3.448	.005	.005	3	1
UCEC	NECTIN2 →	-0.605	-3.437	.003	.005	3	1
UCEC	PIK3C2B →	-1.007	-3.459	<.001	.005	3	1
UCEC	IL21 →	+0.149	+2.512	.001	.003	3	1
LUSC	RNA5SP426 →	+0.318	+7.924	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 83 associations by consensus.

LINC01784 by ZFYVE21 expression — LUSC

Explore this box plot interactively →