ZFYVE21

Across TCGA patient cohorts, ZFYVE21 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZFYVE21-associated genes across cancer lineages are N-Cadherin, XBP1, and Bax. Each is linked with ZFYVE21 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZFYVE21-to-partner and partner-to-ZFYVE21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, N-Cadherin grouped by ZFYVE21-low versus ZFYVE21-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFYVE21→partner) and Y-score (partner→ZFYVE21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	N-Cadherin →	+0.270	+3.169	.020	.020	3	1
UCEC	XBP1 →	+0.155	+3.169	.046	.020	3	1
UCEC	Bax →	+0.271	+3.169	.039	.020	3	1
UCEC	Caspase-7-cleavedD198 →	+0.901	+2.827	.005	.035	3	1
UCEC	c-Met_pY1235 →	+0.093	+3.009	.023	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.184	-3.156	.046	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

N-Cadherin by ZFYVE21 expression — UCEC

Explore this box plot interactively →