ZFYVE16

Across TCGA patient cohorts, ZFYVE16 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZFYVE16-associated genes across cancer lineages are Smad4, ATM, and Notch1. Each is linked with ZFYVE16 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZFYVE16-to-partner and partner-to-ZFYVE16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Smad4 grouped by ZFYVE16-low versus ZFYVE16-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFYVE16→partner) and Y-score (partner→ZFYVE16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Smad4 →	+0.158	+3.178	.016	.010	3	3
UCEC	ATM →	-0.461	-2.156	<.001	.002	3	3
UCEC	Notch1 →	+0.158	+1.784	<.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.486	+1.827	.003	.002	3	2
COAD	PKC-a_pS657 →	-0.387	-3.161	.011	.019	3	1
COAD	TSC1 →	-0.455	-3.161	<.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

Smad4 by ZFYVE16 expression — COAD

Explore this box plot interactively →