ZFYVE1

Across TCGA patient cohorts, ZFYVE1 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZFYVE1-associated genes across cancer lineages are p62 Lck ligand, ATM, and ASNS. Each is linked with ZFYVE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZFYVE1-to-partner and partner-to-ZFYVE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by ZFYVE1-low versus ZFYVE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZFYVE1→partner) and Y-score (partner→ZFYVE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.255	+1.916	.021	.009	3	2
UCEC	ATM →	-0.434	-2.687	.004	.005	3	2
COAD	ASNS →	+0.825	+2.815	<.001	.036	3	1
UCEC	eIF4E →	+0.179	+3.584	.012	.002	3	1
UCEC	A-Raf_pS299 →	-0.087	-1.247	.031	.045	3	1
UCEC	JNK_pT183_Y185 →	-0.135	-1.700	.018	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

p62 Lck ligand by ZFYVE1 expression — UCEC

Explore this box plot interactively →